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When sufficient samples are available and the researcher can apply both methods, the mixed linear model framework is to be preferred. It estimates the variance explained directly from individual-level genotype data, accounting for the correlation structure between the SNPs. Much larger sample sizes, however, are expected to become available in the coming years allowing application of both frameworks to a wide variety of psychiatric diseases, either with direct measures of genetic risk and environment or through proxy-measures of both entities.
They also demonstrated interaction between the GRPS and two environmental factors: parental knowledge and peer deviance.